Radiosensitizers, radioprotectors, and radiation mitigators
نویسندگان
چکیده
منابع مشابه
Radioprotectors and Mitigators of Radiation-Induced Normal Tissue Injury
Radiation is used in the treatment of a broad range of malignancies. Exposure of normal tissue to radiation may result in both acute and chronic toxicities that can result in an inability to deliver the intended therapy, a range of symptoms, and a decrease in quality of life. Radioprotectors are compounds that are designed to reduce the damage in normal tissues caused by radiation. These compou...
متن کاملApplication of Radioprotectors in Radiation Protection
Possibility of protection from ionizing radiation when an organism, as a unit, absorbs radiated energy practically does not exist. In the previous investigations no medicine has been invented that could successfully be applied in therapy of radiation diseases. Today, in the cases of accidental irradiation with high doses of ion radiation and developing of radiation syndrome, today it is possibl...
متن کاملNew Approaches to Radiation Protection
Radioprotectors are compounds that protect against radiation injury when given prior to radiation exposure. Mitigators can protect against radiation injury when given after exposure but before symptoms appear. Radioprotectors and mitigators can potentially improve the outcomes of radiotherapy for cancer treatment by allowing higher doses of radiation and/or reduced damage to normal tissues. Suc...
متن کاملOligoelements Se, Zn, Mn Plus Lachesis Muta as Radioprotectors of Normal Tissues and Radiosensitizers of Malignant Cells
The in vitro effect of O-LM on radiosensitivity of different human cell lines and the in vivo tolerance to high doses of ionizing radiation induced by the combination of Se, Zn and Mn plus Lachesis muta (O-LM) was evaluated. Sprague-Dawley rats received whole-body irradiation with a single dose (2 to 15 Gy) employing a Cs source of 189 TBq (7.7 Gy/min). A half of rats received daily sc O-LM sta...
متن کاملStrategies for Discovery of Small Molecule Radiation Protectors and Radiation Mitigators
Mitochondrial targeted radiation damage protectors (delivered prior to irradiation) and mitigators (delivered after irradiation, but before the appearance of symptoms associated with radiation syndrome) have been a recent focus in drug discovery for (1) normal tissue radiation protection during fractionated radiotherapy, and (2) radiation terrorism counter measures. Several categories of such m...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Indian Journal of Dental Research
سال: 2014
ISSN: 0970-9290
DOI: 10.4103/0970-9290.131142